Peptide-directed interference of PD-1/PD-L1 binding increases B lymphocyte function after infectious bursal disease viral infection
Year: 2024
Type: article
Abstract: : 3.37 nM) and effectively inhibited the PD-1/PD-L1 interaction in vitro. Moreover, gCK-16 significantly enhanced B lymphocyte proliferation. Remarkably, gCK-16 treatment abrogated the IBDV-induced upregulation of PD-1/PD-L1, NF-κB activation, and B lymphocyte apoptosis. Additionally, IBDV infection attenuated PI3K/AKT pathway activation in B lymphocytes, while gCK-16 treatment increased immunoglobulin M (IgM) production in IBDV-infected B lymphocytes. Together, these results demonstrate that gCK-16 treatment can potentially enhance B lymphocyte function against IBDV infection, guiding the development of vaccine adjuvants to effectively prevent IBDV-induced avian immunosuppression.
Source: Poultry Science
Authors: Qiuyu Zhang, Guopeng Sun, Feng Yue, Zhike Liu, Peng Li, Yanping Zhu, Yangzhao Zhu, Ruiyan Niu, Zilong Sun, Xuannian Wang, Gaiping Zhang
Language: English
Subfield: Animal Science and Zoology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,300
Awards: G2834194982, G306773748, G3907005601
OpenAlex ID: W4403272026