Work

High grade renal cell carcinoma in a simultaneous pancreas and kidney transplant recipient

Year: 2024

Type: article

Abstract: INTRODUCTION AND IMPORTANCE: Renal transplant recipients have a higher risk for developing cancers compared to the general population due to high-dose immunosuppression. The risk of renal cell carcinoma (RCC) in native kidneys is 7-fold greater than the general population and development of RCC in an allograft kidney is extremely rare. We report the diagnosis and management of a large RCC in an allograft renal transplant and metastatic disease in a regional lymph node. CASE PRESENTATION: A 46 year old male patient with a history of simultaneous pancreas and kidney transplant presented with visible haematuria. His pancreas allograft continued to function well however following severe BK nephritis his renal transplant failed. A CT urogram demonstrated a 6 cm contrast enhancing mass in the failed renal transplant and an enlarged pelvic lymph node. He underwent a transplant nephrectomy with excision of the metastatic lymph node deposit. CLINICAL DISCUSSION: We report the diagnosis and management of a large RCC in an allograft renal transplant and metastatic disease in a regional lymph node. There is currently no guidelines on the management of allograft RCC. CONCLUSION: Our case report shows that surgical excision of a large RCC in an allograft renal transplant is possible.

Source: International Journal of Surgery Case Reports

DOI: 10.1016/j.ijscr.2024.110420

Authors: Sarah Marie Norton, Clare Norton, Donnacha Hogan, Ponnusamy Mohan

Institution: Beaumont Hospital

Language: English

Topic: Renal cell carcinoma treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,800