A simple and highly efficient catalyst-free for the synthesis of dihydro pyrido[1, 2-a]quinoxaline derivatives by four component reactions and evaluation of their antibacterial activity
Year: 2024
Type: article
Abstract: In the current work, a new series of methyl-10-amino-9-cyano-6-oxo-8-aryl-6,8-dihydro-5 H -pyrido[1,2- a ]quinoxaline-7-carboxylate derivatives were efficiently designed and prepared using a convenient route in excellent yields by four-component reactions among benzene-1,2-diamine, dimethyl acetylenedicarboxylate , various aromatic aldehydes and malononitrile . These reactions were carried out in acetonitrile at ambient temperature under catalyst-free conditions for 7 h. The structures of the new obtained compounds were confirmed by NMR , IR, EI-MS and elemental analysis . The antibacterial activity of the synthesized products was studied using bacterial strains: Staphylococcus aureus , Bacillus subtilis , Escherichia coli , and Pseudomonas aeruginosa . The results showed that all the synthesized compounds are effective against Staphylococcus aureus , Bacillus subtilis and Escherichia coli bacteria.
Source: Results in Chemistry
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,490
OpenAlex ID: W4403274272