Year: 2024
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Gram-negative bacteremia is a life-threatening infection with high morbidity and mortality. Its incidence is rising worldwide, and treatment has become more challenging due to emerging bacterial resistance. Little data is available on the burden and outcome of such infections in Lebanon. METHODS: We conducted this retrospective study in four Lebanese hospitals. Data on medical conditions and demographics of 2400 patients diagnosed with a bloodstream infection based on a positive blood culture were collected between January 2014 and December 2020. RESULTS: Most bacteremias were caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, with the more resistant organisms being hospital-acquired. Third-generation cephalosporin and quinolone resistance was steady throughout the study, but carbapenem resistance increased. Mortality with such infections is high, but carbapenem resistance or infection with Pseudomonas or Acinetobacter species were significant risk factors for poor outcomes. CONCLUSION: This is the first multi-center study from Lebanon on gram-negative bacteremia, resistance patterns, and factors associated with a poor outcome. More surveillance is needed to provide data to guide empirical treatment for bacteremia in Lebanon.
Authors: Janane Nasr, Hilal Abdessamad, Johnathan Mina, Tony Haykal, Yasser Jamil, Emma Abboud, Ahmad Mahdi, Rana Asmar, Rawad Abi Assaad, Dana Alameddine, Alaa Bourji, Mahmoud Mahdi, Razan Abdulaal, Serge Tomassian, Hanane El Ahmadieh, Wael Azzam, Jacques E. Mokhbat, Rima Moghnieh, Alfonso J. Rodriguez-Morales, Rola Husni
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,190
Funder: Lebanese American University
OpenAlex ID: W4403275935