Pathologic In Vivo Assay of the Helicobacter Molecular Infection in Stomach Tissue Using Carbon Nanotube Micro Sensor
Year: 2024
Type: preprint
Abstract: Biomolecular detections of Helicobacter pylori(HP) were compared using specially modified sensors and fluorine immobilized on a carbon nanotube (HFCNT) electrode, which yielded sensitive results. Handheld voltammetric circuits were used for optimization. An anodic voltammogram of HP molecular oxidation was obtained at 0.0 V (versus the Ag/AgCl/KCl) in a 0.1M NH4H2PO4 electrolyte solution. Under optimized conditions, the analytical working range was 2.98x103-22.127x103 CFU/ml HP using square wave (SW) stripping voltammetry, precision of R2 =0.9857 (SWSV), the detection limit approached to 2.5x102 CFU/ml HP (S/N=3).The developed techniques have been applied to diagnosis of early-stage HP infections using stomach tissue from healthy humans and gastric patients.
Source: Preprints.org
Authors: Kyung Lee, Sihyun Jun, Yeseul Oh, Suw Young Ly
Language: English
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4403276090