The PTK2B gene is associated with obesity, adiposity, and leptin levels in children and adolescents
Year: 2024
Type: article
Study design: Observational Study
Abstract: Previous studies determined that Pyk2 is involved in several diseases in which the symptomatology presents alterations in energy balance. However, its role in obesity is poorly understood. To evaluate the metabolic role of the Pyk2 gene ( PTK2B ) in children and adolescents with obesity we measured its mRNA expression levels in peripheral blood mononuclear cells. For that we performed a cross-sectional study involving 130 Caucasian subjects that was divided into two groups according to BMI. Data showed increased PTK2B mRNA expression in children and adolescents with obesity. Interestingly, a positive correlation has been found between the levels of PTK2B with weight, BMI, BMI Z score, fat mass, waist circumference, waist to height ratio, diastolic blood pressure, and leptin. In addition, it is indicated that high levels of PTK2B gene expression might be a predictor of obesity development. This work provides important insights into the previously undescribed role of Pyk2 in obesity.
Source: iScience
Authors: Eva Prida, Raquel Pérez-Lois, Pablo Jácome-Ferrer, Diego Muñoz-Moreno, Beatriz Brea-García, María Villalón, Verónica Pena-Leon, Rocío Vázquez-Cobela, Concepción M. Aguilera, Javier Conde-Aranda, Javier Costas, Ana Estany-Gestal, Mar Quiñones, Rosaura Leis, Luisa María Seoane, Omar Al-Massadi
Institutions: Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Complejo Hospitalario Universitario de Santiago, Centro de Investigación Biomédica en Red, Instituto de Investigación Sanitaria de Santiago, Servicio Gallego de Salud, Universidade de Santiago de Compostela, Universidad de Granada
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,150
Funders: Instituto de Investigación Sanitaria de Santiago de Compostela, European Commission, Federación Española de Enfermedades Raras, Ministerio de Ciencia e Innovación, Axencia Galega de Innovación, Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición, Centro de Investigación Biomédica en Red de Cáncer, Instituto de Salud Carlos III
Awards: OMICAS E INTELINGENCIA ARTIFICAL. HERRAMIENTAS PARA ENTENDER LOS MECANISMOS MOLECULARES DE LA RESISTENCIA A INSULINA EN NIÑOS OBESOS DURANTE LA PUBERTAD., G2662025548, G2737055748, G3122955851, G3830401503, G4224826285, OMICAS E INTELINGENCIA ARTIFICAL. HERRAMIENTAS PARA ENTENDER LOS MECANISMOS MOLECULARES DE LA RESISTENCA A INSULINA EN NIÑOS OBESOS DURANTE LA PUBERTAD., G443141326, Biomarcadores de reprogramación metabólica asociados al efecto protector de la lactancia materna sobre la obesidad y patologías asociadas., G7111321698, Papel de la hormona asprosin en las enfermedades hepáticas
OpenAlex ID: W4403279596