Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons
Year: 2024
Type: article
Abstract: Cochlear implantation (CI) offers a dependable treatment for sensorineural hearing loss, with precision electroacoustic stimulation parameters showing great potential in improving auditory outcomes in CI patients. Here, we report the attachment of MXene into CI systems which effectively mimic the neural electrode interface due to MXene's excellent electrical conductivity and biocompatibility. Low-frequency short-term biphasic electrical pulses emitted by the MXenes-based CI promoted the outgrowth of spiral ganglion neuron (SGN) neurites and growth cones, substantially boosting the calcium activity in SGNs. This study lays a theoretical foundation for the precision medicine approaches in CI patient care, and informs the selection of materials for cochlear implant electrode materials in the future.
Source: Engineered Regeneration
Institutions: Nantong University, Zhongda Hospital Southeast University, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing Drum Tower Hospital, Nanjing University, University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Shandong University, Fudan University, Eye & ENT Hospital of Fudan University, State Key Laboratory of Medical Neurobiology, Frontiers Center for Brain Science of the Ministry of Education
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $700
Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation, Natural Science Foundation of Jiangsu Province, Natural Science Foundation of Beijing Municipality, Shenzhen Fundamental Research Program, National Postdoctoral Program for Innovative Talents, National Key Research and Development Program of China, National Key Research and Development Program of China Stem Cell and Translational Research
OpenAlex ID: W4403286261