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Tocilizumab, a Humanized Anti-interleukin-6 Receptor Antibody, Induces Hepatic Iron Overload in a Susceptible Patient

Year: 2024

Type: article

Abstract: A 75-year-old woman visited to our hospital with liver dysfunction. The patient's liver function was normal. She had been treated with tocilizumab for rheumatoid arthritis for two years. One year after initiation of tocilizumab treatment, liver dysfunction was observed. Serum ceruloplasmin concentration was low. We diagnosed hepatic iron overload because of a high ferritin concentration and a liver biopsy. The cessation of tocilizumab and phlebotomy improved the liver function. We believe that tocilizumab induced iron accumulation. We should be aware of the possibility that tocilizumab induces iron overload in susceptible patients and monitor iron status in patients treated with tocilizumab.

Source: Internal Medicine

DOI: 10.2169/internalmedicine.4329-24

Authors: Masaru Harada, Yuichi Honma, Eisuke Shiba, Naohisa Tomosugi, Riko Harada

Institutions: University of Occupational and Environmental Health Japan, Kanazawa Medical University

Language: English

Topic: Iron Metabolism and Disorders

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4403289593

FWCI: 0.268

Cites: 18

Cited by: 1

Related to: 10