Get started
Work

Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages in situ

Year: 2024
Type: article
Abstract: interstitial subsets, associated with distinct sub-anatomic territories. These populations were selectively reduced by blockade of CSF1, CSF2, CCR2, and CX3CR1 and efficiently reconstitute their spatial distribution after transient myelo-ablation, suggesting an autonomous regulatory environment. Our findings emphasize the organization of the MP compartment at the sub-anatomic level under steady-state conditions, thereby providing a holistic understanding of their relative heterogeneity across different tissues.
Source: Cell Reports
DOI: 10.1016/j.celrep.2024.114847
Authors: Maxime Petit, Eléonore Weber-Delacroix, François Lanthiez, Sandrine Barthélémy, Noëlline Guillou, Marina Firpion, Olivia Bonduelle, David A. Hume, Christophe Combadière, Alexandre Boissonnas
Institutions: Centre National de la Recherche Scientifique, Inserm, Sorbonne Université, Pitié-Salpêtrière Hospital, Centre d'Immunologie et des Maladies Infectieuses, Production et analyse de données en sciences de la vie et en santé, Translational Research Institute, The University of Queensland, University of Bristol, Mater Research
Language: English
Subfield: Immunology
Open Access status: gold
Estimated APC paid: $5,460
Funders: Bristol-Myers Squibb Foundation, Association pour la Recherche sur le Cancer, Agence Nationale de la Recherche, Institut National Du Cancer, Sorbonne Université, National Health and Medical Research Council
Awards: G2485713848, G3621621690, Therapeutic evaluation of the blockage of chemokine receptors (Ccr2 or Cx3cr1) in the chronic ocular pain., Role of Kupffer cells in hypercholesterolemia-driven cardiovascular risk, Macrophage Biology in Health and Disease, G7080048889
OpenAlex ID: W4403289844
FWCI: 1.226
Cites: 69
Cited by: 9
Related to: 10