Work

Emergence of advanced immunotherapy: New horizons for HPV-negative head and neck squamous cell carcinoma

Year: 2024

Type: article

Abstract: Head and neck squamous cell carcinoma (HNSCC) is a complex group of malignancies that exhibit distinct clinical and molecular characteristics, especially in the HPV-negative subset. The treatment landscape for HPV-negative HNSCC has historically been limited to surgery, radiation, and chemotherapy, with these modalities often yielding suboptimal outcomes. The emergence of advanced immunotherapy represents a paradigm shift, offering new therapeutic options for this challenging cancer type . This review provides a comprehensive analysis of the latest advancements in immunotherapy for HPV-negative HNSCC, focusing on, chimeric antigen receptor (CAR) T-cell therapy, therapeutic cancer vaccines and immune checkpoint inhibitors . It also explores the potential benefits and limitations of combining immunotherapy with other treatment modalities including chemotherapy, targeted therapy , and radiation. Key challenges, including tumor heterogeneity , immunosuppressive microenvironment, and resistance mechanisms, are discussed. The review concludes with a look at future research directions and strategies to overcome these challenges and improve patient outcomes.

Source: Oral Oncology Reports

DOI: 10.1016/j.oor.2024.100670

Authors: Madhan Krishnan, Shyamaladevi Babu, M.V. Vinaya Kumar, Rajasekaran Subbarayan

Institution: Chettinad Academy of Research and Education

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,100