Work

One‐Pot Three‐Component Synthesis of Some 6‐Methoxy‐2‐Naphthyl Pyrimidinones with Molecular Docking and Biological Activities Studies

Year: 2024

Type: article

Abstract: A new series of 6‐methoxy‐2‐naphthalene based pyrimidinones were synthesized via one pot‐three component synthetic reaction of aryl aldehydes, 6‐methoxy‐2‐acetonapthone and urea in the presence of nano zinc ferrite catalyst under conventional method. The synthesized compounds were characterized by their spectral techniques including FT‐IR, H 1 , C 13 NMR, LCMS, and analysis of elements. Molecular docking analysis was also performed to identify the protein‐ligand interactions and binding energy of synthesized compounds. Biological studies of all synthesized pyrimidinone compounds have been measured against bacterial and fungal strains by calculating the zone of inhibition.

Source: ChemistrySelect

DOI: 10.1002/slct.202402276

Authors: Jaganathan Divya, Paneerselvam Gayathri, Inbasekaran Muthuvel, Sugumaran Suguna, Ganesamoorthy Thirunarayanan

Institutions: Annamalai University, Government of Tamil Nadu

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Department of Science and Technology, Ministry of Science and Technology, India

OpenAlex ID: W4403293410

FWCI: 0.141

Cites: 32

Cited by: 1

Related to: 10