Work

Regiodivergent Radical-Relay Alkene Dicarbofunctionalization

Year: 2024

Type: article

Abstract: Herein, we report a regiodivergent 1,n-dicarbofunctionalization of unactivated olefins enabled by a Ni-catalyzed radical relay that forges both C( sp 3 )-C( sp 3 ) and C( sp 2 )–C( sp 3 ) linkages, even at long-range. Initial studies support an intertwined scenario resulting from the merger of an atom-transfer radical addition (ATRA) and a chain-walking event, with site-selectivity being dictated by a judicious choice of the ligand backbone.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.4c10204

Authors: Zhong Liu, Francesco D’Amico, Ruben Martin

Institutions: Institut Català d'Investigació Química, Barcelona Institute of Science and Technology, University of Siena, Institució Catalana de Recerca i Estudis Avançats

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Ministerio de Ciencia, Innovación y Universidades, European Commission, Institut Català d'Investigació Química, HORIZON EUROPE Marie Sklodowska-Curie Actions