Work

Mitochondrial proteostasis in axons: key roles for neuronal health

Year: 2024

Type: article

Abstract: Neurons integrate perception, motor, and cognitive functions, relying heavily on mitochondria for ATP production to support axonal transport, synaptic activity, and maintenance of membrane potential. Mitochondrial dysfunction disrupts energy supply, increases oxidative stress, and impairs calcium buffering, contributing to axonal degeneration in neurodegenerative diseases. Mitochondria are strategically located and transported within highly polarised neurons, posing the problem of maintaining functional organelles in axonal and dendritic regions far away from the cell body. This article highlights mechanisms that ensure the quality of the mitochondrial proteome in neurons.

Source: BIOspektrum

DOI: 10.1007/s12268-024-2319-2

Authors: Marta Zaninello, Elena I. Rugarli

Institutions: University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,090