Work

Live-Cell-Imaging-Analysen mit Crumbs2-Varianten

Year: 2024

Type: article

Abstract: Crumbs2 (CRB2) is a novel, less-studied key component of the renal filtration barrier and part of the slit diaphragm formed by podocytes. Some CRB2 variants have been linked to inherited forms of proteinuric diseases from childhood. However, the pathogenic potential of many CRB2 variants is still unknown. Here we report the development of a simple but robust live-cell imaging-based system, allowing a first evaluation about the pathogenic potential of novel CRB2 variants.

Source: BIOspektrum

DOI: 10.1007/s12268-024-2299-2

Authors: Annika Möller-Kerutt, Thomas Weide

Institution: University Hospital Münster

Language: English

Topic: Renal Diseases and Glomerulopathies

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,090