Work

ER-Phagie und Neurodegeneration

Year: 2024

Type: article

Abstract: Autophagy is a process to target substrates for lysosomal degradation, which starts with the enclosure of the substrate by the LC3-labelled isolation membrane and the subsequent fusion with lysosomes. Selectivity of this process can be achieved via autophagy receptors. In recent years, several receptors which target ER subdomains for degradation via autophagy (reticulophagy or ER-phagy) have been described. Some of which are associated with neurodegenerative disorders.

Source: BIOspektrum

DOI: 10.1007/s12268-024-2301-z

Authors: Christian A. Hübner, Ivan Ðikić

Institutions: Jena University Hospital, Friedrich Schiller University Jena, Goethe University Frankfurt

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,090