From Bench to Bedside: A Team’s Approach to Multidisciplinary Strategies to Combat Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma
Year: 2024
Type: article
Abstract: Head and neck squamous cell carcinoma (HNSCC) is diagnosed in more than 71,000 patients each year in the United States, with nearly 16,000 associated deaths. One significant hurdle in the treatment of HNSCC is acquired and intrinsic resistance to existing therapeutic agents. Over the past several decades, the University of Wisconsin has formed a multidisciplinary team to move basic scientific discovery along the translational spectrum to impact the lives of HNSCC patients. In this review, we outline key discoveries made throughout the years at the University of Wisconsin to deepen our understanding of therapeutic resistance in HNSCC and how a strong, interdisciplinary team can make significant advances toward improving the lives of these patients by combatting resistance to established therapeutic modalities. We are profoundly grateful to the many scientific teams worldwide whose groundbreaking discoveries, alongside evolving clinical paradigms in head and neck oncology, have been instrumental in making our work possible.
Source: Journal of Clinical Medicine
DOI: 10.3390/jcm13206036
Authors: Bridget E. Crossman, Regan L. Harmon, Kourtney L. Kostecki, Nellie K. McDaniel, Mari Iida, Luke W. Corday, Christine E. Glitchev, Madisen T. Crow, Madelyn A. Harris, Candie Y. Lin, Jillian M. Adams, Colin A. Longhurst, Kwangok P. Nickel, Irene M. Ong, Roxana A. Alexandridis, Menggang Yu, David T. Yang, Rong Hu, Zachary S. Morris, Gregory K. Hartig, Tiffany A. Glazer, Sravani Ramisetty, Prakash Kulkarni, Ravi Salgia, Randall J. Kimple, Justine Y. Bruce, Paul M. Harari, Deric L. Wheeler
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,955
OpenAlex ID: W4403301805