An experimental investigation of decompressive craniectomy in a rat model of hemispheric stroke treated with decompressive craniectomy
Year: 2024
Type: article
Abstract: Aims: Acute ischemia can lead to severe edema in the brain, increased intracranial pressure and coma progression and death through cingular, uncal or tonsillar herniation in all the territories of the carotid artery. It is well established that cerebral and cardiovascular surgery patients benefit from decompressive craniectomy, although there is less data on how they do with regard to other forms of ischemia. In this study, we analyze the results of an experimental study on the decompressive craniectomy effects that occurs at various times after occlusion of the endovascular middle cerebral artery (MCA) in rats. Methods: The endovascular occlusion procedure was done in 80 rats, resulting in focal ischemia. 4, 12, 24 and 36 hours after vessel occlusion decompressive craniectomies were done in 60 rats (each in groups of 15 rats). Decompressive craniectomy was not carried out on 20 specimens (control group). At day seven we used the number of infarcts and the neurological performance as endpoints. Results: No animals infected with decompressive craniectomy died despite a mortality rate of 35 percent in untreated communities (mortality 0 percent). Both early or late treatment with a decompressive craniectomy dramatically improved neurologic function in both species. Compared to that animals that underwent endovascular occlusion of the per hour for 4 hours after their traumatic brain injury and did not have their brains decompressed, the infarction and neurological function showed statistically significant improvement after the 2 to 4 hours period (p<0.01) intervention. A new study has concluded that decompressive craniectomy care reduces mortality and increases the quality of life. Right after the outset of the formation of an occlusion, the infarct period is reduced. During a stroke treatment for head injury neurosurgeons may use neurochirons to decompress the brain. Conclusion: Cerebral vascular insufficiency decompressive craniectomy works well after the vessel is clamped eliminates the infarction. Craniectomy performed within 4 hours of surgery will restore lives, neurological results are not improved or infarction levels are minimized just as effectively as craniectomy immediately after vessel occlusion. A randomized pilot study of the clinical support is provided for the concept of providing an immediate and aggressive treatment for those who have mid-grade internal carotid artery (ICA) and MCA occlusion neurosurgeons may play an important role in the treatment of patients with stroke by decompressive craniectomy.
Source: Ankyra Medical Journal
DOI: 10.51271/ankmj-0024
Author: Fahri Eryılmaz
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4403303317