Work

The Role of Cellular Plasticity of Vascular Wall Cells and Hematopoietic System in Atherogenesis

Year: 2024

Type: article

Abstract: Highlights The atherosclerotic process is caused by phenotypic heterogeneity and cellular plasticity of the immune system and vascular wall. Somatic mutations and clonal hematopoiesis with uncertain potential demonstrate a close association with cardiovascular diseases and acute vascular events. Abstract The last decade of cardiogenetic studies focused on inherited germline mutations. Recently researchers demonstrated a significant role of cellular heterogeneity, somatic mosaicism, and clonal hematopoiesis in the risk of coronary disease and acute vascular disorders. Up-to-date technologies, such as single-cell sequencing and mass cytometry, have made it possible to reveal fundamentally new mechanisms for the development of cardiovascular diseases. This review discloses cutting-edge data on atherosclerosis and vascular disorders, focusing on cellular heterogeneity, somatic mosaicism, and clonal hematopoiesis.

Source: Complex Issues of Cardiovascular Diseases

DOI: 10.17802/2306-1278-2024-13-3-105-110

Author: Alexey A. Sleptsov

Institutions: Russian Academy of Sciences, Research Institute of Medical Genetics of Russian Academy of Medical Sciences, Tomsk National Research Medical Center

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4403315782

FWCI:

Cites: 48

Cited by:

Related to: 10