Non-Familial and CYLD Gene Mutation Negative Brooke–Spiegler Syndrome Associated with Human Immunodeficiency Virus: A Case Report
Year: 2024
Type: article
Study design: Case Report
Abstract: Brooke–Spiegler syndrome is a rare autosomal dominant disorder characterised by the presence of various adnexal tumours including multiple cylindromas, trichoepitheliomas and spiradenomas. This is a case of a 52-year-old female, on antiretroviral therapy who presented with numerous painless nodules over her forehead, scalp and face for 3 years. The asymptomatic skin-coloured nodules extended from the forehead to the post-auricular region and measured 2–6 cm in size. Histopathology of the larger lesion showed cylindroma, the medium-sized lesion showed spiradenoma and the smaller skin-coloured papules showed trichoepithelioma. There was no history of similar lesions in the family and no other symptoms suggestive of any systemic involvement.
Language: English
Topic: Cancer and Skin Lesions
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4403315907