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Figure S4 from ATR Inhibition Induces CDK1–SPOP Signaling and Enhances Anti–PD-L1 Cytotoxicity in Prostate Cancer

Year: 2024

Type: other

Abstract: Supplementary Figure S4 shows ATRi or ATR siRNA knockdown downregulates PD-L1 protein expression in RM-1-BM prostate cancer cells (immunoblot analysis), and SPOP siRNA transfection does not alter PD-L1 mRNA levels in RM-1-BM and C4-2b prostate cancer cells (suggesting SPOP post-transcriptional regulation of PD-L1 expression).

DOI: 10.1158/1078-0432.27205414

Authors: Zhe Tang, Patrick G. Pilié, Chuandong Geng, Ganiraju C. Manyam, Guang Yang, Sanghee Park, Daoqi Wang, Shan Peng, Cheng Wu, Guang Peng, Timothy A. Yap, Paul G. Corn, Bradley M. Broom, Timothy C. Thompson

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4403319149

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