Work

Successful Treatment of Severe Pyoderma Gangrenosum and Ulcerative Colitis With Upadacitinib

Year: 2024

Type: article

Abstract: Pyoderma gangrenosum (PG) is a rare inflammatory and ulcerative skin disorder that is often associated with an underlying systemic disease, including inflammatory bowel disease. Many treatments used to treat inflammatory bowel disease are also used for the treatment of PG, including systemic therapies, immunomodulators, and tumor necrosis factor-α inhibitors; however, their efficacy in PG is limited. Novel treatments of PG are needed. We report the case of a 62-year-old woman with steroid-refractory PG and concomitant ulcerative colitis successfully treated for both conditions with upadacitinib, a selective Janus kinase inhibitor.

Source: ACG Case Reports Journal

DOI: 10.14309/crj.0000000000001531

Authors: Sarah Park, Joelle St Pierre, Oluwakemi Onajin, David T. Rubin

Institutions: University of Chicago, University of Chicago Medical Center

Language: English

Topic: Autoimmune and Inflammatory Disorders

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4403319430

FWCI: 2.596

Cites: 20

Cited by: 10

Related to: 10