Year: 2024
Type: review
Abstract: Delirium and dementia are common causes of cognitive impairment in older adults. They are distinct but interrelated. Delirium, an acute confusional state, has been linked to the chronic and progressive loss of cognitive ability seen in dementia. Individuals with dementia are at higher risk for delirium, and delirium itself is a risk factor for incident dementia. Additionally, delirium in individuals with dementia can hasten underlying cognitive decline. In this review, we summarize recent literature linking these conditions, including epidemiological, clinicopathological, neuroimaging, biomarker, and experimental evidence supporting the intersection between these conditions. Strategies for evaluation and diagnosis that focus on distinguishing delirium from dementia in clinical settings and recommendations for delirium prevention interventions for patients with dementia are presented. We also discuss studies that provide evidence that delirium may be a modifiable risk factor for dementia and consider the impact of delirium prevention interventions on long-term outcomes.
Source: Seminars in Neurology
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Novel Blood Biomarker of Alzheimer's disease Using Oral Glucose Tolerance, Does vestibular loss predict falls in patients with Alzheimer's Disease?, Polygenic Risk and Inflammation in Delirium and Alzheimer's disease, Shared Pathophysiology of Postoperative Delirium and Alzheimer's Disease and Related Dementias, Brain Vulnerability in Delirium and Alzheimer’s Disease and Related Dementias: Intersection of Polygenic Risk and Inflammation, Utilizing Technology and AI Approaches to Facilitate Independence and Resilience in Older Adults, Health Services and Outcomes Research for Aging Populations, Older Americans Independence Center, Addressing Hearing Loss as a Common Unmet Contributor to Neuropsychiatric Symptoms
OpenAlex ID: W4403321592