Work

Synthesis of N-Bromo and N-Iodo Imides: A Rapid Redox-Neutral and Bench Stable Process

Year: 2024

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide This report presents a rapid, ecofriendly technique for the formation of commonly used N -bromo and N -iodinating reagents by reacting readily available N -chloro derivatives with inorganic bromide and iodide salts. All reagents were easily handled, commercially available, and bench stable. This strategy illustrates the expeditious formation of these halogenating reagents in multigram scale in high-yields and purity with an operationally straightforward recrystallization. The mechanistic details suggest an in situ generation of an interhalogen species.

Source: Organic Process Research & Development

DOI: 10.1021/acs.oprd.4c00194

Authors: Ankush Chakraborty, Bardia Soltanzadeh, Nicholas R. Wills, Arvind Jaganathan, Babak Borhan

Institution: Michigan State University

Language: English

Topic: Oxidative Organic Chemistry Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funder: National Institute of General Medical Sciences