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Maternal exposure to polystyrene nanoplastics induces sex-specific cardiotoxicity in offspring mice

Year: 2024

Type: article

Abstract: macrophage infiltration in offspring hearts. Notably, PS-NPs induced distinct cardiovascular diseases in the offspring. Fluid shear stress and atherosclerosis were significantly enriched in PS-NP-treated male offspring, while viral myocarditis was predominantly enriched in PS-NP-treated females. Our findings suggest that PS-NPs induce cardiotoxicity in offspring by disrupting metabolism, impairing immunity, and triggering fibrosis and apoptosis, with sex-specific differences. This study provides novel insights and a foundation for understanding sex-specific pharmacological differences and interventions in PS-NP-induced cardiovascular disease in offspring.

Source: Heliyon

DOI: 10.1016/j.heliyon.2024.e39139

Authors: Xiuli Chen, Shenzhen Huang, Li Wang, Kan Liu, Haiying Wu

Institutions: Henan University, Zhengzhou University, Henan Provincial People's Hospital, Henan Provincial Eye Hospital

Language: English

Topic: Microplastics and Plastic Pollution

Subfield: Pollution

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,100