High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus
Year: 2024
Type: article
Study design: Observational Study
Abstract: Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than average blood glucose levels. Here, we use blood samples and constant glucose monitoring (CGM) data obtained from people living with type 1 diabetes (T1D) to determine the effects of glycemic variability on the ex vivo T cell response to influenza virus. We show that high glycemic variability in participants living with T1D is associated with a reduced proportion of CD8 + CD107a − IFNγ − MIP1β − TNF + T cells in response to stimulation with influenza virus and an influenza virus peptide pool. Thus, this study provides evidence that glycemic variability affects the ex vivo T cell response to respiratory viruses. These data suggest that monitoring glycemic variability may have important implications in understanding the antiviral immune response in people with diabetes.
Source: iScience
Authors: Marcus Z.W. Tong, Katina D. Hulme, Soi Cheng Law, Ellesandra Noye, Emily S. Dorey, Keng Yih Chew, Louise C. Rowntree, Carolien E. van de Sandt, Katherine Kedzierska, Marco Goeijenbier, Katharina Ronacher, Fawaz Alzaid, Jean-Baptiste Julla, Jean-Pierre Riveline, Katie E. Lineburg, Corey Smith, Emma J. Grant, Stephanie Gras, Linda A. Gallo, Helen L. Barrett, Kirsty R. Short
Institutions: The University of Queensland, Amsterdam UMC Location University of Amsterdam, University of Amsterdam, Translational Research Institute, Mater Research, The University of Melbourne, Peter Doherty Institute, Sanquin, Amsterdam University Medical Centers, Erasmus MC, Spaarne Ziekenhuis, Spaarne Gasthuis, Centre National de la Recherche Scientifique, Inserm, Université Paris Cité, Institut Necker Enfants Malades, Dasman Diabetes Institute, Assistance Publique – Hôpitaux de Paris, Hôpital Lariboisière, QIMR Berghofer Medical Research Institute, La Trobe University, University of the Sunshine Coast, Royal Hospital for Women, UNSW Sydney
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,150
Awards: G1215074449, Decoding the evolution of killer T cell immunity across human lifetime, Harnessing optimal anti-viral CD8+ T cell immunity for high-risk populations, G557338938, G5596325893, Pandemic-proofing our future, The investigation of an unconventional Human Leukocyte Antigen molecule, G7443916703, T cell-mediated responses to influenza and Human Immunodeficiency virus (HIV) infection, The role of glycaemic variability in influenza virus pathogenesis and immunity, Harnessing universal immunity to influenza
OpenAlex ID: W4403325370