High Prevalence of Carbapenem-resistant Klebsiella Pneumoniae in Fecal and Water Samples in Dhaka, Bangladesh
Year: 2024
Type: article
Study design: Observational Study
Abstract: We evaluated Klebsiella pneumoniae (Kp) gut carriage in healthy, unrelated adults and children living in separate households in Dhaka, Bangladesh. Average Kp prevalence in stool samples ranged from 61% in young children (15/25) to 81% in adults (21/26), with significantly higher abundance in adults (P = .03, t-test). Kp was also prevalent in household water (64%, 21/33) and standing water (85%, 23/27). The presence of Kp in household water was not strongly linked to stool Kp abundance among household members. Antimicrobial resistance was notable: 9% (6/69) of stool and 16% (7/44) of water isolates exhibited multidrug resistance. Carbapenem resistance was observed in 12% of stool isolates (8/69) and 14% of water isolates (6/44). These findings underscore the commonality of Kp in human and environmental reservoirs in Dhaka, Bangladesh, and highlight the emergence of drug-resistant Kp beyond healthcare settings.
Source: Open Forum Infectious Diseases
DOI: 10.1093/ofid/ofae612
Authors: Sanchita Kar, Zannat Kawser, Sushmita Sridhar, Sharmin Aktar Mukta, Neamul Hasan, Abu Bakar Siddik, Mohammad Tanbir Habib, Damien M Slater, Ashlee M Earl, Colin J Worby, Kasrina Azad, S M Shamsuzzaman, Nusrat Noor Tanni, Raisa Tasnia Khan, Meherunnisa Moonmoon, Firdausi Qadri, Jason B Harris, Regina C LaRocque
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,256
OpenAlex ID: W4403329094