Work

The role of cholesterol crystals and ocular crystal emboli in retinal pathology

Year: 2024

Type: article

Abstract: Cholesterol crystals (CC) can be responsible for a range of clinical syndromes in the retina from asymptomatic plaques to retinal artery occlusion with clinical trials providing evidence for the efficacy in lipid lowering therapies in preventing ocular pathology. Much of the literature has focused on CC in retinal circulation as a marker of poor systemic health and have attempted to use them to categorize risk of mortality and stroke. More recently cholesterol accumulation and CC formation have been linked to development of diabetic retinopathy with CC formation in the retina due to aberrant retinal cholesterol homeostasis and not simply systemic dyslipidemia.

Source: American Heart Journal Plus Cardiology Research and Practice

DOI: 10.1016/j.ahjo.2024.100475

Authors: Nicholas G. Medawar, Tim F. Dorweiler, George S. Abela, Julia V. Busik, Maria B. Grant

Institutions: University of Alabama at Birmingham, Boston Children's Hospital, Michigan State University, University of Oklahoma

Language: English

Topic: Retinal Diseases and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,650