Work

Efficient Dehydration of 1-Phenylethanol to Styrene by Copper(II) and Zinc(II) Fused-Bisoxazolidine Catalysts

Year: 2024

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide The air-stable copper(II) catalyst [Cu( meso FOX-L1)(MeCN)][OTf] 2 ( 2a ) is prepared from a fused meso-dipyridylbisoxazolidine ( meso FOX-L1) and CuBr 2, followed by treatment with AgOTf. The compound is a catalyst for the dehydration of 1-phenylethanol to styrene (+H 2 O) in over 95% yield at 1 mol % catalyst loading. Other alcohols (benzylic, tertiary, or allylic) are also efficiently dehydrated by this catalyst. Water separation in toluene solvent is found to play an important role in the reaction. Related compounds with Zn(II) have been prepared and display reduced dehydration activity.

Source: ACS Catalysis

DOI: 10.1021/acscatal.4c04572

Authors: Aurodeep Panda, Caroline R. Wood, William W. Brennessel, William D. Jones

Institution: University of Rochester

Language: English

Topic: Chemical Synthesis and Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: National Science Foundation, Chemical Sciences, Geosciences, and Biosciences Division