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Challenges in Managing Cytomegalovirus Colitis in a Complex Case of Ulcerative Colitis With Hyposplenism and Ustekinumab Therapy

Year: 2024

Type: article

Abstract: ABSTRACT Colitis secondary to cytomegalovirus (CMV) infection is a recognized complication in patients with ulcerative colitis. This case report details a patient with a background of ulcerative colitis with resultant hyposplenism on ustekinumab therapy who presented with CMV colitis. The presence of hyposplenism with the use of ustekinumab resulted in challenges when treating the CMV infection due to the absence of immune response and required individual tailoring of therapy with higher doses of ganciclovir and valganciclovir according to trough level measurement.

Source: ACG Case Reports Journal

DOI: 10.14309/crj.0000000000001536

Authors: Natalie G Hung, Sameer Malik, Charlotte Cachia, Theresa Ly, Rupert Leong

Institutions: Concord Repatriation General Hospital, NSW Health Pathology

Language: English

Topic: Cytomegalovirus and herpesvirus research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4403334533

FWCI: 0.265

Cites: 17

Cited by: 1

Related to: 10