Work

Polyinosinic-polycytidylic acid modulates Porphyromonas gingivalis-induced cell apoptosis via the janus kinase/ signal transducer and activator of transcription signaling pathway

Year: 2024

Type: article

Abstract: Background/Purpose: . Materials and methods: , both with and without Poly (I:C) treatment; additionally, the activation status of the JAK/STAT signaling pathway was assessed. Results: The administration of Poly (I:C) diminished apoptosis in the aortic root cells of mice, enhanced the expression of the anti-apoptotic protein Bcl-2, and decreased the levels of Bax, Caspase 3 and 9. Furthermore, Poly (I:C) exhibited similar effects on HUVECs cultured in vitro. Additionally, treatment with Poly (I:C) activated the JAK/STAT signaling pathway, while STAT inhibitor was found to attenuate its effects. Conclusion: -induced cellular apoptosis, with the involvement of the JAK/STAT signaling pathway in this mechanism.

Source: Journal of Dental Sciences

DOI: 10.1016/j.jds.2024.09.021

Authors: Shengnan Zhang, Jianru Liu, Xiangying Ouyang, Wenyi Liu, Yuanbo Wang, Jinsheng Zhong

Institution: Peking University

Language: English

Topic: Cytokine Signaling Pathways and Interactions

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,200