Work

Spermatogenic Stem Cells: Core Biology, Defining Features, and Utilities

Year: 2024

Type: review

Abstract: The actions of spermatogenic stem cells (SSCs) provide the foundation for continual spermatogenesis and regeneration of the cognate lineage following cytotoxic insult or transplantation. Several decades of research with rodent models have yielded knowledge about the core biology, morphological features, and molecular profiles of mammalian SSCs. Translation of these discoveries to utilities for human fertility preservation, improving animal agriculture, and wildlife conservation are actively being pursued. Here, we provide overviews of these aspects covering both historical and current states of understanding.

Source: Molecular Reproduction and Development

DOI: 10.1002/mrd.23777

Authors: Tessa Lord, Jon M. Oatley

Institutions: Hunter Medical Research Institute, University of Newcastle Australia, Washington State University

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,060