Work

lncRNA WAC-AS1 promotes the progression of gastric cancer through miR-204-5p/HOXC8 axis

Year: 2024

Type: article

Abstract: • LncRNA plays an important role in many life activities, such as epigenetic regulation, cell cycle regulation and cell differentiation regulation. • LncRNA WAC-AS1 was identified significantly upregulated in gastric cancer and affected the progression of gastric cancer. • LncRNA WAC-AS1 through miR-204-5p/HOXC8 axis significantly promoted the proliferation, migration and invasion of gastric cancer. LncRNAs affect tumorigenesis, and although the genesis, regulation and physiological mechanism of lncRNAs in gastric cancer (GC) have been reported, the research of lncRNAs still have a lot of value. Through comprehensive bioinformatics analysis, we screened the candidate lncRNA WAC-AS1(WAC-AS1). We analyzed WAC-AS1 expression in GC related tissues and cells using qRT-PCR. WAC-AS1’s impact on GC growth and metastasis was investigated. LncRNA WC-AS-miR-204-5p-HOXC8 interaction was established through dual-luciferase reporter, FISH, RIP and RNA pull-down assay. We observed substantial upregulation in WAC-AS1 expression in cells and tissues of GC. WAC-AS1 through miR-204-5p/HOXC8 axis promoted GC proliferation, invasion, and migration. WAC-AS1 plays a cancer-promoting role for promoting the progression of GC.

Source: Translational Oncology

DOI: 10.1016/j.tranon.2024.102139

Authors: Yan Liu, Kaixuan Li, Yongjian Gao, Ye Feng, Xiaoling Zhao, Ruizhi Hou

Institutions: Jilin University, Tengzhou Central People's Hospital, Capital Medical University, Beijing Children’s Hospital

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,130