Work

Design, Synthesis and Characterization of 5-(2-Bromo-5-Fluorophenyl)-3-(1h-Pyrrol-2-Yl)-4,5-Dihydro-1h-Pyrazole as Antifungal Agent

Year: 2024

Type: article

Abstract: This study successfully synthesized a novel compound (5-(2-bromo-5-fluorophenyl)-3-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole (6), from an α, β-unsaturated carbonyl compound (5). The compound was characterized using various spectroscopic techniques, including 1???? NMR, 13???? NMR, and mass spectrometry. Its antifungal potential was evaluated against three fungal strains including Candida tropicalis, Candida parapsilosis, and Candida albicans. The results indicated that compound (6) exhibited moderate antifungal activity. Furthermore, molecular descriptors and ADMET profiling were employed in an in-silico simulation to assess the compound's drug-likeness. This study thus presents a valuable strategy for developing more effective antifungal agents.

Source: Revista Electronica de Veterinaria

DOI: 10.69980/redvet.v25i1s.1189

Author: Chandra Shekhar Yadav

Institutions: Central Drug Research Institute, Integral University, Council of Scientific and Industrial Research

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

OpenAlex ID: W4403341068

FWCI: 0.141

Cites:

Cited by: 1

Related to: 10