Get started
Work

Piperine exerts anti-inflammatory effects and antagonises the properties of celecoxib and ketoprofen: in vivo and molecular docking studies

Year: 2024
Type: article
Abstract: This study evaluates the anti-inflammatory effects of a natural product, piperine (PPN), using in vivo and in silico methodologies. In the in vivo segment, inflammation was induced in the right hind paw of young chicks via a formalin (50 μL) injection. PPN was orally administered at doses of 25 and 50 mg/kg with or without celecoxib (CXB) and/or ketoprofen (KPN) (42 mg/kg). The vehicle acted as the negative control group (NC). The in silico analysis predicted the drug-likeness, pharmacokinetics, and toxicity profile of PPN, along with evaluating its binding affinity and ligand-receptor interactions. Results indicate that PPN significantly (p < 0.05) reduced licking frequency and paw edoema in a dose-dependent manner. However, in combination therapy, PPN diminished the effects of both CXB and KPN. PPN showed high affinity (–8.6 kcal/mol) towards the COX-2 enzyme. Therefore, PPN exerts anti-inflammatory effects in chicks through COX-2 inhibition pathways and antagonises CXB and KPN activities.
DOI: 10.1080/14786419.2024.2413039
Authors: Rubel Hasan, Md. Shimul Bhuia, Raihan Chowdhury, Muhammad Ali Khan, Modhurima Mazumder, Noshin Tasnim Yana, Marcus Vinícius Oliveira Barros de Alencar, Siddique Akber Ansari, Irfan Aamer Ansari, Muhammad Torequl Islam
Institutions: Gopalganj Science and Technology University, BioLuster Research Center Ltd, Instituto Superior de Teologia Aplicada, King Saud University, University of Turin, Khulna University
Language: English
Subfield: Pharmacology
Open Access status: green
OpenAlex ID: W4403341244
FWCI: 3.659
Cites: 85
Cited by: 10
Related to: 10