Year: 2024
Type: article
Study design: Observational Study
Abstract: Aim: This study investigates the relationship between metabolic risk and urological outcome in men with LUTS at 10 years.Method: This is a retrospective review of prospectively recruited patients with LUTS presenting to a secondary urology centre.Details of their metabolic and urological status were collected at baseline.The outcome of 10-year acute urinary retention (AUR) was reviewed.Framingham score was used to assess the metabolic risk and to stratify patients into low, intermediate and high cardiovascular risk groups.Men with previous prostatic surgery, urological cancer or neurogenic bladder were excluded.For statistical analysis, t-test, chi-square test, logistic regression analysis and survival analysis were performed.Results: From March 2006 to August 2013, 2005 men were recruited.Their mean age was 66.2 ± 8.6 years, with 49% having hypertension and 19% having diabetes.At 10 years, 306 patients (15.3%) developed AUR.Men with subsequent AUR had a higher Framingham score (17.7 ± 4.1 vs. 16.6 ± 4.3, p < .001)and a higher serum PSA level (6.5 ± 5.6 vs. 3.8 ± 5.4, p < .001).Multivariate analysis consistently showed that a higher Framingham score (OR1.04,p = .017)and a higher serum PSA level (OR1.06,p < .001)were associated with a higher risk of 10-year AUR.Patients were further stratified by their PSA level.With a serum PSA≤4 (p < .001),patients with a high metabolic risk were more likely to develop AUR than with an elevated PSA >4 ( p = .233).Conclusion: Metabolic profile is associated with the incidence of 10-year AUR among men with LUTS, particularly when they have a normal serum PSA level.
Source: Surgical Practice
Author: This study investigates the relationship between metabolic risk and urological outcome in men with LUTS at 10 years.
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4403343198