Work

Challenges and opportunities of next generation therapeutics: A compound management perspective

Year: 2024

Type: article

Abstract: In recent years, pharmaceutical research has increased its interest in novel drug modalities beyond small molecules to overcome therapeutic limitations and find more effective cures. Compound Management teams globally are adapting their processes and equipment to handle such "new modalities" with the same quality and speed as small molecule research. Here, we share our approach in supporting next-generation therapeutics by introducing solutions for multi-solvent workflows in Compound Management at AstraZeneca. From sample submission to assay-ready plate generation, we describe the challenges faced and process improvements introduced so far. Collaborating with our business partners, we are pioneering new best practices and laying solid foundations for future research to bring new efficacious drugs into the clinics.

Source: SLAS TECHNOLOGY

DOI: 10.1016/j.slast.2024.100201

Authors: Silvio Di Castro, Martin L. Svensson

Institution: AstraZeneca (Sweden)

Language: English

Topic: Protein purification and stability

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,800