Evaluate the Role of A. Baumannii in Promoting Inflammation and Meningitis-Related Genes in Various Immune Cells
Year: 2024
Type: article
Abstract: The role of Acinetobacter baumannii in promoting inflammation in spleenocyte and lymph node cells has been studied by detecting the gene expression of four different genes that are related to meningitis, which was performed after treatment of laboratory animal cells with dead cells of A. baumannii, the results of gene expression by using Real Time- Quantitative PCR and graph prism software exhibited the presence of statistical differences between A. baumannii treated and non-treated laboratory animal cells. All genes showed an expression between one and a half (1.5) to more than 40 (>40) fold change. The NLRP has expression in the spleen and lymph nodes between the (2-10) folds, which increase after being activated with killed A. baumannii cells. NF Kappa B has expression in the spleen and lymph nodes between (1.5-6) fold increase after being activated with killed A. baumanniicells. GMCSF has expression in the spleen and lymph nodes between (30-40) fold increase after being activated with killed A. baumannii cells. IL-1B has expression in the spleen and lymph nodes between (4.5-40) fold increase after being activated with killed A. baumannii cells.
Authors: Rafal Majid Mukhlif, Bashar Sadiq Noomi
Institution: University of Tikrit
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4403358581