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Investigation of bioactive metabolites produced by the endophytic fungus Aspergillus iranicus from Houttuynia cordata Thunb

Year: 2024

Type: article

Abstract: The endophytic fungus Aspergillus iranicus, capable of producing bioactive substances, was isolated from the roots of Houttuynia cordata Thunb. Through chromatographic methods, five compounds were isolated in this study for the first time from the fermentation broth and mycelia of the endophytic fungus Aspergillus iranicus obtained from Houttuynia cordata Thunb. using ethyl acetate extracts. These compounds were identified as palmitic acid (1), protocatechuic acid (2), 4-hydroxybenzophenone (3), stigmasterol (4), and β-sitosterol (5). The IC50 values for compound 2 was 1.32 mg/mL, which indicate strong DPPH radical scavenging activity. Compounds 2, 3, and 5 significantly inhibited the growth of Escherichia coli, demonstrating MIC values of 6.25, 3.13, and 3.13 mg/mL, respectively. Additionally, displaying a MIC value of 0.78 mg/mL, compound 3 demonstrated remarkable inhibition against Candida albicans growth. These findings suggest the presence of endophytic fungi in H. cordata, producing several valuable medicinal secondary metabolites.

Source: Natural Product Research

DOI: 10.1080/14786419.2024.2412836

Authors: Jiayue Rao, Zhaoyang Tao, Jianshu Chen, Shengli Yang

Institution: Zhejiang University of Technology

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Science and Technology Department of Zhejiang Province