Work

Natural compounds and derivatives as modulators of multidrug resistance and their mechanisms of action: recent studies in vitro, in vivo and in silico

Year: 2024

Type: article

Abstract: Drug resistance used in chemotherapy is a common challenge in cancer treatment. The present review of resistance-modulating molecules in cancer recapitulates in vitro, in vivo, and in silico studies of flavonoids, lactones, taxanes, curcuminoids, catechins, and chalcones stand out among others. The main mechanisms of action involve inhibiting the overexpression and function of efflux proteins and altering signaling pathways related to resistance. For their part, the discussed in silico studies identified key interactions between modulating molecules and multidrug resistance (MDR) transporters. This information supports research on synthetic modifications to create new scaffolds for reversing MDR and minimizing toxicity.

Source: Discover Applied Sciences

DOI: 10.1007/s42452-024-06239-9

Authors: Jessica Nayelli Sánchez-Carranza, Shawa Verónica Montes-Helguera, Adriana Valladares-Méndez, Enrique Salas-Vidal, Leticia González-Maya

Institutions: Universidad Autónoma del Estado de Morelos, Universidad Nacional Autónoma de México

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Universidad Nacional Autónoma de México