Cutaneous Manifestations of COVID-19 Vaccination and COVID-19 Infection: a Questionnaire-based, Multi-center Study in Korea
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause various cutaneous complications, including dermatologic adverse reactions to SARS-CoV-2 vaccines reported by several studies. Objective: To describe the clinical characteristics of cutaneous complications of SARS-CoV-2 infection and adverse reactions to SARS-CoV-2 vaccines, and to determine the risk factors for cutaneous manifestations. Methods: A questionnaire-based survey in 12 hospitals in Korea. Results: After receiving SARS-CoV-2 vaccinations, 20.23% and 5.94% of the respondents reported new-onset cutaneous lesions or aggravation of preexisting cutaneous conditions, respectively. Respondents who developed new cutaneous lesions after COVID-19 were significantly older than those who did not (p = 0.001). Systemic symptoms of SARS-CoV-2 vaccination (fever, chill, cough, sore throat, and myalgia) were associated with higher risk for new-onset cutaneous lesions (p < 0.05). Myalgia was the only systemic symptom of SARS-CoV-2 vaccination that was associated with higher risk for the aggravation of preexisting cutaneous conditions (p = 0.011). Following coronavirus 2019 (COVID-19) diagnosis, 13.3% and 9.7% of the respondents reported new skin lesions and aggravation of preexisting cutaneous conditions, respectively. Respondents with new cutaneous lesions were significantly older than those without new cutaneous lesions (p = 0.046). Systemic COVID-19 symptoms were significantly more common in respondents who developed new cutaneous lesions than in those who did not (p < 0.001). The proportion of respondents with underlying autoimmune diseases was significantly higher in those with cutaneous COVID-19 complications than in those without such complications (p = 0.038). Conclusion: This study offers insights into the characteristics of cutaneous manifestations of SARS-CoV-2 vaccination and infection in Korea.
Institutions: Asan Medical Center, University of Ulsan, Pusan National University Hospital, Pusan National University, Inje University Busan Paik Hospital, Chosun University, Chosun University Hospital, Daegu Catholic University Medical Center, Jeonbuk National University Hospital, Hanyang University, Kyung Hee University, Konkuk University Medical Center, Catholic University of Korea, Kyungpook National University, National Medical Center
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4403371679