Longitudinal associations of life space mobility and domain-specific cognitive measures in ACTIVE
Year: 2024
Type: article
Abstract: We tested the longitudinal associations between life space mobility (LSM) at baseline and cognitive performance in three domains (memory, reasoning, and speed of processing) over time. Our analytic sample includes 2,690 older adults (mean age = 73.0, 75.9% female) participating in the ACTIVE Study. We used multiple linear mixed-effects models to evaluate whether LSM, measured using the Life Space Questionnaire, at baseline was longitudinally associated with scores on eight cognitive tests and three composite scores across 10 years. In unadjusted models, there were significant main effects of baseline LSM on memory and reasoning domains, and one speed of processing test (beta: 0.019 to 0.055, p < 0.05). All effects were non-significant in adjusted models. Over time, baseline LSM was associated with one memory test score in adjusted models. Greater LSM at baseline is associated with marginally higher cognitive performance but does not appear to affect the rate of cognitive change at a clinically significant level.
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Indiana University, University of Florida, Johns Hopkins University, Pennsylvania State University, University of Alabama, New England Research Institutes, National Institutes of Health, School of Medicine, Indiana University, National Institute on Aging, National Institute of Nursing Research
Awards: G1247343150, G1492665292, G15558500, G1882526043, G2059235590, ACTIVE Phase III: HRC Field Site, G225545633, G2396893096, Sedative-Hypnotic Use Patterns and Risk for Cognitive Decline and Alzheimer's Disease, ACTIVE Phase III: JHU Field Site, G307324232, G4438921143, UAB Alzheimer's Disease Research Center, G5176264939, G5337856074, G5401253916, G5741906230, G625660684, G6581352804, G6709451946, G6711873528, G7455245913, G7871987278, G7889262951, ACTIVE Coordinating Center, G8880810126, G9000017220, G9000041075, G9000051215, G9000117492, G9000151207, G9000158613, G9000168003, G9000233169, G9000307441, G9000315449, G9000328266, University of Florida Older Americans Independence Center (OAIC), Socioeconomic and Cardiovascular Sources of Cross-National Variation in Cognitive Health Among Older Adults, Integrating Information about Aging Surveys: Novel Integration of Contextual Data to Study Late-Life Cognition and Alzheimer’s Disease and Related Dementia and Dementia Care
OpenAlex ID: W4403375315