Value of narcotrend anesthesia depth monitoring in predicting POCD in gastrointestinal tumor anesthesia block patients
Year: 2024
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: The purpose of this research was to evaluate the efficacy of Narcotrend (NT) monitoring on cognitive dysfunction in patients undergoing anesthesia blockade for gastrointestinal tumors and its effect on cerebral oxygen metabolism and inflammatory response. Patients preparing to undergo resection of gastrointestinal tumor resection were included and randomly divided into a control group (depth of anesthesia assessed by physician experience) and a research group (depth of anesthesia monitored by NT). HR and MAP were monitored at the preoperatively (T 0 ), 12 h postoperative (T 1 ), 24 h postoperative (T 2 ), and 48 h postoperative (T 3 ) stages. MMSE score was recorded to assess changes in cognitive function. Intracerebral oxygenation indicators (CjvO 2 , CERO 2, and rSO 2 ) were assessed by a blood gas analyzer. ELISA assay was conducted to explore the serum inflammatory indexes (CRP, IL-1β, and TNF-α) and neurological function indicators (NSE and MBP). MAP was higher in the research group than in the control group at T 1 and T 2 ( P < 0.05). MMSE scores at T1, T2, and T3 stages were higher in the research group than in the control ( P < 0.05). The incidence of POCD was also lower in the research group compared with the control ( P < 0.05). CjvO 2 , CERO 2, and rSO 2 were significantly higher ( P < 0.05) and were positively correlated with the MMSE scores. Postoperative serum inflammatory indexes were significantly elevated in both groups, but more significantly in the control group ( P < 0.05). Both neurological function indicators were usually reduced after surgery, but the reduction was more significant in the research group ( P < 0.05). NT monitoring of anesthetic depth has a less physical impact on patients with gastrointestinal tumor anesthetic block, reduces the degree of postoperative POCD, and has significant clinical value.
Source: BMC Anesthesiology
Authors: Xizhong Ma, Xueli Zhao, Ruina Guo, Zhixun Hu, Jianghong Liu, Hongfeng Nie
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,990
OpenAlex ID: W4403378912