Exploring Dengue Infection in a Vaccinated Individual: Preliminary Molecular Diagnosis and Sequencing Insights
Year: 2024
Type: article
Study design: Case Report
Abstract: This study examines a case involving a 7-year-old child who developed dengue symptoms following Qdenga vaccination. Despite initial negative diagnostic results, molecular analysis confirmed an infection with DENV4. Next-generation sequencing detected viral RNA from both DENV2 and DENV4 serotypes, which were identified as vaccine-derived strains using specific primers. Phylogenetic analysis further confirmed that these sequences belonged to the Qdenga vaccine rather than circulating wild-type viruses. This case underscores the critical need for precise diagnostic interpretation in vaccinated individuals to avoid misdiagnosis and to strengthen public health surveillance. A comprehensive understanding of vaccine-induced viremia is essential for refining dengue surveillance, improving diagnostic accuracy, and informing public health strategies in endemic regions.
Source: Viruses
DOI: 10.3390/v16101603
Authors: Talita Émile Ribeiro Adelino, Sílvia Helena Sousa Pietra Pedroso, Maurício Lima, Luiz Marcelo Ribeiro Tomé, Natália Rocha Guimarães, Vagner Fonseca, Paulo Eduardo de Souza da Silva, Keldenn Melo Farias Moreno, Ana Cândida Araújo e Silva, Náthale Rodrigues Pinheiro, Carolina Senra Alves de Souza, Luiz Carlos Junior Alcantara, Marta Giovanetti, Felipe Campos de Melo Iani
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,955
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Ministério da Saúde, Fundação Oswaldo Cruz, Universidade Federal de Minas Gerais, National Institutes of Health, Pan American Health Organization, National Institute of Allergy and Infectious Diseases
Awards: G1125103630, G1406499450, G1619822945, G1724689450, G1762666261, G1880986580, G3059246303, G3197568622, G3262104648, G3911635593, G5256340532, VIGILÂNCIA GENÔMICA DOS POXVIRUS, G6213605192, G6326007206, G7217461782, G7697130546, REDE UAI-ARBO-MG: REDE UNIFICADA DE ANÁLISES INTEGRADAS DE ARBOVÍRUS DE MINAS GERAIS., G7861227495, G8460953515, G9000056580, G9000264621, G9000346859
OpenAlex ID: W4403379442