Year: 2024
Type: article
Abstract: Two novel ibuprofen cystamine salts (IBU‐CYS 1 and IBU‐CYS 2) are synthesized by coupling the anion of ibuprofen with cystamine dihydrochloride in 1 : 1 and 2 : 1 ratio to improve the solubility and bioavailability of ibuprofen. The salts are characterized by 1H NMR, FT‐IR and UV‐Vis spectroscopy, differential scanning calorimetry (DSC), thermogravimetry (TGA, DTA) and X‐ray diffraction measurements. IBU‐CYS 1 and IBU‐CYS 2 show higher solubility (6.11 and 7.81 mg/mL) compared to ibuprofen (0.04 mg/mL) in water. IBU‐CYS2 was encapsulated into 2‐hydroxyethyl methacrylate: poly (ethylene glycol) acrylate hydrogels for enhanced delivery. The in vitro studies in PBS (pH 7.4) indicate that the salts are effective in relieving inflammatory responses induced by lipopolysaccharide in RAW264.7 macrophage cells (nitrite inhibition percentages of IBU‐CYS 1, IBU‐CYS 2 and ibuprofen: approximately 34.29, 27.03 and 31.50 respectively) while indicating no cytotoxicity. Therefore, these salts may be promising candidates for the development of effective formulations of this drug.
Source: ChemistryOpen
Institutions: Boğaziçi University, Yeditepe University
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,540
OpenAlex ID: W4403381373