Effect of gut microbiota intervention on inflammatory responses and cellular immune function in hepatocellular carcinoma patients undergoing radiotherapy
Year: 2024
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: To analyze the changes in nutritional status, inflammatory response and cellular immune status of Hepatocellular Carcinoma (HCC) patients who received radiotherapy under GMB intervention and to clarify the effect of GMB intervention on HCC. Ninety-two patients with HCC receiving radiotherapy were randomized into study and observation groups, 46 in each group. The control group used conventional radiotherapy, and the study group used the gut microbiota intervention. The gut microbiota before and after radiotherapy, and the liver function, clinical efficacy, inflammatory response, cellular immunity, and nutritional status before and after treatment were compared. Compared with the control group, the number of lactobacillus and Bifidobacterium increased significantly, the clinical efficacy was significantly enhanced, the liver function, cellular immunity and nutritional status were significantly improved, and the inflammatory response was significantly reduced, with statistically significant differences (P < 0.05). gut microbiota intervention can improve the effect of radiotherapy and improve liver function in patients, and the mechanism is related to regulating cellular immune function of patients and inhibiting inflammatory response in patients.
Authors: Liying Liu, Yanna Fan, Hongying Pi
Institution: Chinese PLA General Hospital
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,400
OpenAlex ID: W4403383944