Work

A Convenient Synthesis of CHF2O-Containing Pyrrolidines and Related Compounds — Prospective Building Blocks for Drug Discovery

Year: 2024

Type: article

Abstract: Fluorine-containing organic molecules, including CHF2O derivatives, are among the most sought-after in medicinal chemistry. In the current work, a mini-library of 21 compounds with a CHF2O motif incorporated with azetidine, pyrrolidine (proline), piperidine, 2-azabicyclo[2.2.1]heptane, and 8-azabicyclo[3.2.1]octane cores was synthesized. A multigram scale (10–30 g) procedure for synthesizing the title compounds from commercially available amino alcohols was studied.

Source: SynOpen

DOI: 10.1055/s-0040-1720142

Authors: Kostiantyn Levchenko, Ivan Virstiuk, Daria Menshykova, Nazariy Pokhodylo

Institutions: Lviv University, Enamine (Ukraine), National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $340

Funders: Simons Foundation, Ministry of Education and Science of Ukraine