An Improved Gold(I) Catalytic System for the Preparation of Coumarins via Intramolecular Cyclization
Year: 2024
Type: article
Abstract: A catalytic system comprising a gold(I) complex with an N‐heterocyclic carbene (NHC) ligand in an ionic liquid as solvent exhibits higher catalytic efficiency compared to state of the art systems in the title reaction, which enables using down to 0.01 mol % gold. A commercial gold(I) catalyst such as IPrAuNTf2 can be employed for this purpose. In the case of less reactive substrates bearing electron‐withdrawing substituents at the phenol moiety, a tailor made NHC‐gold(I) precatalyst exhibits improved reactivity and can be advantageously employed compared to the commercial one.
Source: Chemistry - An Asian Journal
Authors: Francesco Ravera, Federico Floreani, Cristina Tubaro, Marco Roverso, Riccardo Pedrazzani, Marco Bandini, Andrea Biffis
Language: English
Topic: Catalytic Alkyne Reactions
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,430
Funder: Università degli Studi di Padova
OpenAlex ID: W4403385930