Work

Organocatalyzed Asymmetric Conjugate Addition of Cyclic β‐Keto Esters to (E)‐β‐Nitroacrylate Derivatives

Year: 2024

Type: article

Abstract: A diaminomethylenemalononitrile organocatalyst efficiently promoted the asymmetric conjugate addition of cyclic β-keto esters to (E)-β-nitroacrylate derivatives, yielding the corresponding β-nitro esters derivatives with excellent enantioselectivities (up to >99 % ee). This is the first successful example of highly stereoselective conjugate addition of cyclic β-keto esters to (E)-β-nitroacrylate derivatives to obtain anti-isomers.

Source: Chemistry - An Asian Journal

DOI: 10.1002/asia.202401029

Authors: Yasuyuki Matsushima, Yoshiyuki Iijima, Chinatsu Tanabe, Kosuke Nakashima, Shin‐ichi Hirashima, Tsuyoshi Miura

Institution: Tokyo University of Pharmacy and Life Sciences

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,430

Funder: Japan Society for the Promotion of Science