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Innumerable Culture-Negative Intracranial Abscesses in an Immunocompetent Young Male Diagnosed by 16s rRNA Gene Sequencing

Year: 2024

Type: article

Abstract: Here, we present a case of a healthy young man with an initial presentation concerning for infectious encephalitis later found on neuroimaging to have extensive intracranial lesions. Pathological analysis of these lesions was consistent with a bacterial intraparenchymal abscess; however, cultures were negative for a causative organism. Results of gene sequencing from an abscess sample were consistent with Streptococcus intermedius infection. Streptococcus intermedius, a β-hemolytic gram-positive species of the Streptococcus anginosus group (SAG), is known to possess several virulence factors that promote abscess formation.

Source: Cureus

DOI: 10.7759/cureus.71475

Authors: Ronald A Miller, Yeonsoo Kim, Vasyl Pryshliak, Timothy M Beutler

Institution: SUNY Upstate Medical University

Language: English

Topic: Infectious Diseases and Tuberculosis

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4403387560