Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus
Year: 2024
Type: article
Abstract: Inhibitory interneurons are pivotal components of cortical circuits. Beyond providing inhibition, they have been proposed to coordinate the firing of excitatory neurons within cell assemblies. While the roles of specific interneuron subtypes have been extensively studied, their influence on pyramidal cell synchrony in vivo remains elusive. Employing an all-optical approach in mice, we simultaneously recorded hippocampal interneurons and pyramidal cells and probed the network influence of individual interneurons using optogenetics. We demonstrate that CA1 interneurons form a functionally interconnected network that promotes synchrony through disinhibition during awake immobility, while preserving endogenous cell assemblies. Our network model underscores the importance of both cell assemblies and dense, unspecific interneuron connectivity in explaining our experimental findings, suggesting that interneurons may operate not only via division of labor but also through concerted activity.
Source: PLoS Biology
Authors: Marco Bocchio, Artem Vorobyev, Sadra Sadeh, Sophie Brustlein, Robin Dard, Susanne Reichinnek, Valentina Emiliani, Agnes Baude, Claudia Clopath, Rosa Cossart
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,500
Funders: Wellcome Trust, Marie Curie, European Commission, Agence Nationale de la Recherche, Centre National de la Recherche Scientifique, Fondation Bettencourt Schueller, Fondation Roger de Spoelberch, Horizon 2020 Framework Programme, European Research Council, H2020 Marie Skłodowska-Curie Actions
Awards: G2001806450, G2140688951, The role of GABAergic circuits in the orchestration of hippocampal neuronal assemblies, G3345895242, G336214659, G3362287031, G4003788947, G413193060, G434337789, Shedding light on hub cell function in vivo, G4835561499, G4937468798, G5646196883, G5839897825, Memory research: Ground-breaking, Applied, and Technological Exchanges, G6329715174, Perturbative analysis of brain networks, The role of GABAergic circuits in the orchestration of hippocampal neuronal assemblies, Memory research: Ground-breaking, Applied, and Technological Exchanges, G7147191618, G79047614, G7984235579, G8019869205, G8512683158, G8591720154
OpenAlex ID: W4403390012